Ko te Integrin, ko te integrin ranei, ko te heterodimer transmembrane glycoprotein receptor e takawaenga ana i te adhesion pūtau kararehe me te tohu.Kei te titoα aβ nga waahanga iti.Kei te whai waahi ki te arotautanga o nga momo mahi pūkoro tae atu ki te heke o te pūtau, te kuhutanga o te pūtau, te tohu pūtau me te tohu intercellular, te piri pūtau, me nga tukanga angiogenesis.Whakauruαvβ3 kei te torotoro whanui ake inaianei.Ko te ahua o te integrinαvβKo te 3 he hononga tata ki te heke pukupuku, te angiogenesis, te mumura me te osteoporosis.Ko te Integrin e tino whakaatuhia ana i roto i nga kopa puku katoa me nga kiriuhi pūtau endothelial o te neovascularization.Ko te ahua o te integrin e hono tata ana ki te hekenga pukupuku me te angiogenesis.I nga tau tata nei, kua whakaatuhia e nga rangahau pūtaiao he 11 nga whakaurunga ka taea te hono motuhake ki te RGD peptide, he peptides antagonistic mo nga kaiwhakawhiwhi integrin.
Ko te RGD peptide kua whakarōpūhia ki te raina RGD peptide me te RGD cyclic peptide.Ka whakatauritea ki te RGD peptide raina, RGD cyclic peptide he kaha ake te hototahi kaikawe me te motuhake o te kaikawe.Ko nga momo noa me nga tikanga whakahiato o te RGD cyclic peptide e whai ake nei.
Momo noa o te RGD cyclic peptides:
1. peptides Cyclic kei roto nga raupapa RGD i hangaia e nga here disulfide
2. Ko nga peptides cyclic kei roto nga raupapa RGD i hangaia e nga here amide
Te whakahiato o te RGD cyclic peptide:
Ko te tauira whaipainga e pa ana ki te RGD cyclic peptide synthesis process in the field of solid phase polypeptide synthesis technology.Ko te tikanga hou ko te kowhiri i te kapia 2-chloro-triphenylmethyl chloride hei kaikawe o mua, hono tuatahi te roopu carboxyl mekameka taha tuatahi me tetahi roopu whakamarumaru motuhake o te waikawa amino D aspartic acid, katahi ka honoa te peptide raina o te RGD raupapa peptide ki te kapia. , me te waikawa amino whakamutunga hei tango i te roopu tiaki FMOC kaore he piperidine.Ko te whakakorikori kua tohua hei tango i te roopu whakamarumaru carboxyl taha taha o te waikawa aspartic D tuatahi mai i te kapia, ka whai i te taapiri o te piperidine ki te tango i te roopu tiaki amino FMOC o te waikawa amino mutunga, ka whai i te taapiri o te kaihoko here. ki te whakamakuku me te whakamaarama i te roopu carboxyl me te roopu amino e kitea ana mai i te upoko me te pito o te peptide raina tika mai i te kapia i te ahua o te here amide hei whakaputa i te peptide cyclic.Ka mutu, ka tapahia tikahia te peptide hurihanga mai i te kapia me te otinga tapahi.
Te wa tuku: Apr-24-2023