Cilengitide/188968-51-6/GT Peptide/Peptide Kaiwhakarato

Whakaahuatanga

C(RGDf-Me-V) mowhiti ingoa Hainamana (L-arginyl-glycyryl-L-aspartyL-D-phenylalanyl-N-methyl-L-valyl), cilengitide.Ko te cChemicalbookilengitide (EMD-121974) he peptide cyclic c [RGDf(N-Me)V] kei roto te raupapa RGD i hoahoatia e te tohunga kemu Tiamana Kessler.Cilengitidehe peptide pentapeptide cyclic e whakataetae ana mo te raupapa peptide arginine-glycine-aspartic acid (RGD).Ka whakarite i te herenga integrin-ligand.Cilengitidema te whiriwhiri me te whai hua ki te aukati i te alpha v beta 3 beta me te alpha v 5 integrin kua honoa ki nga pūmua matrix, penei i te Vitronectin, Fibrinogen me von Willebrand Factor, Osteopontin, me etahi atu.I aukatihia te BAE e te 10μKo te MCilengitide me te taapiri o nga pūtau BME me HUVE ki Vitronectin me Fibronectin..

Whakatakotoranga

Te ahua: Ma te paura ma ki te paura ma

Pure(HPLC):≥98.0%

Te poke kotahi:≤2.0%

Ihirangi Acetate(HPLC): 5.0%～12.0%

Ihirangi wai (Karl Fischer):≤10.0%

Ihirangi Peptide:≥80.0%

Te Taapaki me te Tukunga: Te iti o te pāmahana, te whakakakahu korehau, te tika ki te mg ka hiahiatia.

Me pehea te Ota?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Ota ipurangi.Whakakiia koa te puka tono tuihono.

3. Whakaratohia te ingoa peptide, te nama CAS, te raupapa ranei, te ma me te whakarereke ki te hiahiatia, te nui, me etahi atu ka tukuna e matou he korero i roto i nga haora 2.

4. Whakaritenga ota ma te kirimana hoko kua hainatia me te NDA(whakaaetanga kore korero) me te whakaaetanga muna ranei.

5. Ka whakahou tonu matou i te ahunga whakamua i roto i te waa.

6. Ko te tuku peptide na DHL, Fedex, etahi atu ranei, me te HPLC, MS, COA ka tukuna me te uta.

7. Ka whaihia te kaupapa here whakahoki mena he rereketanga o to maatau kounga, ratonga ranei.

8. Ratonga muri-hoko: Mena he patai a taatau kiritaki mo to maatau peptide i te wa o te whakamatautau, me pai ki te whakapiri mai ki a maatau ka whakautuhia e matou i roto i te wa poto.

Ko nga hua katoa o te kamupene ka whakamahia noa mo te kaupapa rangahauiao, na's kua rāhuitia kia whakamahia tika e tetahi tangata ki te tinana tangata.

FAQ：

I whakahekehia nga peptides kei roto Cys i mua i te tuku?

Mena karekau te peptide i kitea kua oxidized, kaore matou e whakaiti i te Cys.Ko nga polypeptides katoa ka riro mai i nga hua parakore kua purea me te lyophilized i raro i nga tikanga pH2, he iti rawa te aukati i te whakapouritanga o Cys.Ko nga Peptides kei roto Cys ka purea ki te pH2 mena kaore he take motuhake hei pure i te pH6.8.Mena ka mahia te purenga ki te pH6.8, me rongoa tonu te hua kua purea ki te waikawa kia kore ai e mate.I roto i te taahiraa whakahaere kounga whakamutunga, mo nga peptides kei roto Cys, ki te kitea te noho o te matū taumaha (2P+H) i runga i te mahere MS, e tohu ana kua hanga he dimer.Mena kaore he raruraru ki a MS me HPLC, ka tukuna e matou nga taonga me te kore he tukatuka atu.Me tohu ko nga peptide kei roto a Cys he puhoi te whakamaaramatanga i roto i te waa, a ko te tohu o te waiora ka whakawhirinaki ki te raupapa peptide me nga tikanga rokiroki.

Me pehea koe ki te whakatau mena he peptide kei te takahurihia?

Ka whakamahia e matou te tauhohenga a Ellman ki te whakamatautau mena kua oti te hanga mowhiti.Mena he pai te whakamatautau a Ellman (kowhai), kaore i oti te tauhohenga mowhiti.Mena he kino nga hua whakamatautau (ehara i te kowhai), kua oti te tauhohenga mowhiti.Kaore matou e whakarato i te ripoata tātaritanga o te tohu tohu paihikara mo o taatau kiritaki.Ko te tikanga, he whakaahuatanga mo nga hua whakamatautau a Ellman i roto i te purongo QC.

Kei te hiahia ahau ki te peptide cyclic, kei roto he tryptophan, ka oxidized?

Ko te oxidation o te tryptophan he ahuatanga noa i roto i te peptide oxidation, a ko te nuinga o nga wa ka pahikohia nga peptides i mua i te purenga.Mena ka puta te oxidation o te tryptophan, ka huri te wa pupuri o te peptide i runga i te pou HPLC, ka taea te tango i te waiora ma te purenga.I tua atu, ka taea hoki te kite i nga peptides oxidized e MS.

Me whakatakoto he mokowhiti i waenga i te peptide me te waikano?

Mena kei te whakapiri koe i tetahi ngota ngota nui (penei i te waikano) ki te peptide, he pai ake te whakatakoto i te mokowhiti i waenganui i te peptide me te ligand hei whakaiti i te pokanoa ki te kaiwhiwhi ma te kopaki o te peptide ake, ma te kopaki ranei o te peptide. tona whakakotahitanga.Ko etahi kaore e hiahia ana ki nga waahi.Hei tauira, i roto i te whakakopa i nga pūmua, ka taea te whakatau he pehea te tawhiti o te hanga kopa o te waikawa amino ma te whakapiri i te waikano rewharewha ki tetahi waahi.

Mena kei te pirangi koe ki te whakarereke i te koiora i te tauranga N, me whakatakoto he mokowhiti i waenga i te biotin me te raupapa peptide?

Ko te tikanga tapanga biotin paerewa e whakamahia ana e to taatau kamupene ko te whakapiri i tetahi Ahx ki te mekameka peptide, ka whai ko te biotin.Ko Ahx he pūhui waro-6 e mahi ana hei arai i waenga i te peptide me te biotin.

Ka taea e koe te tuku tohutohu mo te hoahoa o nga peptides phosphorylated?

Ka piki haere te roa, ka heke haere te pai o te here mai i te waikawa amino phosphorylated ki runga ake.Ko te ahunga whakahiato mai i te tauranga C ki te tauranga N.E taunaki ana kia kaua e neke ake i te 10 nga toenga i muri i te waikawa amino phosphorylated, ara, ko te maha o nga toenga waikawa amino i mua i te waikawa amino phosphorylated mai i te tauranga N ki te tauranga C kia kaua e neke ake i te 10.

He aha te acetylation-n-terminal me te amidation-terminal C?

Ko enei whakarereketanga ka aukati i te peptide ki te whakaheke me te tuku i te peptide ki te whakataurite i tona ahuatanga taketake o nga roopu alpha amino me te carboxyl i roto i te pūmua matua.